By John S. Bradley MD, John D. Nelson MD Emeritus, Dr. David W Kimberlin MD FAAP, Dr. John A.D. Leake MD MPH, Dr. Paul E Palumbo MD, Dr. Jason Sauberan PharmD, Dr. William J Steinbach
New twentieth Edition! This bestselling and popular source on pediatric antimicrobial treatment offers immediate entry to trustworthy, up to date options for remedy of all infectious ailments in youngsters.
For every one disorder, the authors offer a remark to assist overall healthiness care prone decide on the simplest of all antimicrobial choices. Drug descriptions conceal all antimicrobial brokers on hand this day and comprise entire information regarding dosing regimens. in line with turning out to be matters approximately overuse of antibiotics, this system contains guidance on whilst to not prescribe antimicrobials.
Practical, evidence-based suggestions from the specialists in antimicrobial treatment:
Developed via exotic editorial board
Designed in case you look after young ones and are confronted with judgements each day
Includes remedy of parasitic infections and tropical medicine.
Updated checks in regards to the power of the suggestion and the point of proof for therapy techniques for significant infections
Anti-infective drug directory, entire with formulations and dosages
Antibiotic treatment for overweight children
Antimicrobial prophylaxis/prevention of symptomatic infection
Maximal grownup dosages and better dosages of a few antimicrobials customary in children
Read Online or Download 2014 Nelson's Pediatric Antimicrobial Therapy PDF
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Extra resources for 2014 Nelson's Pediatric Antimicrobial Therapy
G Doses listed are for meningitis or Pseudomonas infections. Can give 60 mg/kg/day div q12h for treatment of non-CNS infections caused by enteric bacilli (eg, E coli, Klebsiella, Enterobacter, Serratia) as they are more susceptible to cefepime than Pseudomonas. h Usually avoided in neonates. Can be considered for transitioning to outpatient treatment of GBS bacteremia in well-appearing neonates at low risk for hyperbilirubinemia. i Desired serum concentration 15–25 mg/mL. j Loading dose 25 mg/kg followed 24 hours later by maintenance dose listed.
If MSSA isolated, use: oxacillin/nafcillin IV OR cefazolin IV Cellulitis, orbital53–55 (usually secondary to sinus infection; caused by respiratory tract flora and S aureus, including CA-MRSA) C. EYE INFECTIONS Antimicrobial Therapy According to Clinical Syndromes Clinical Diagnosis 44 — Chapter 6. indb 45 No antibiotic usually needed; oral therapy for more symptomatic infection, based on Gram stain and culture of pus; topical therapy as for conjunctivitis may be helpful. 66 Cefepime IV, meropenem IV, or imipenem IV are alternatives (no clinical data).
Gentamicin is synergistic in vitro with ampicillin. Continue until clinical and microbiological response documented (AIII). Duration of therapy not well defined, consider 5 days Cefotaxime is preferred for infants with hyperbilirubinemia. Meropenem or cefepime for gentamicin/cefotaxime-resistant coliforms (eg, Enterobacter, Serratia) (AIII) Meropenem for ESBL-producing coliforms (AIII) Gentamicin needed with either ampicillin or vancomycin for bactericidal activity; continue until clinical and microbiological response documented (AIII) For vancomycin-resistant enterococci that are also ampicillin resistant: linezolid (AIII) Alternative: clindamycin, but increasing resistance reported Cefotaxime preferred if meningitis suspected or cannot be excluded (AIII).
2014 Nelson's Pediatric Antimicrobial Therapy by John S. Bradley MD, John D. Nelson MD Emeritus, Dr. David W Kimberlin MD FAAP, Dr. John A.D. Leake MD MPH, Dr. Paul E Palumbo MD, Dr. Jason Sauberan PharmD, Dr. William J Steinbach