By John A. Borrelli, Ylenia D. Giannini
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Extra resources for Advances in Viral Genomes Research
A. and N. Frenkel, Replication of herpes simplex virus DNA: localization of replication recognition signals within defective virus genomes. Proc Natl Acad Sci U S A, 1981. 78(2): p. 742-6. A. A. Schaffer, Cloning and characterization of herpes simplex virus type 1 oriL: comparison of replication and proteinDNA complex formation by oriL and oriS. J Virol, 1995. 69(3): p. 137788. J. M. Wilkie, Nucleotide sequences of the joint between the L and S segments of herpes simplex virus types 1 and 2. J Gen Virol, 1981.
These mice developed behavioral deficits after 4 weeks, resembling FA. In an attempt to generate a treatment for FA, the authors injected a second amplicon vector, bearing the cDNA of frda wt. These mice exhibit behavioral recovery as early as 4 weeks after the second vector injection . Taking advantage of the large capacity of amplicon vectors, GomezSebastian and collaborators used amplicons to deliver a 135-kb insert containing the entire frda wt human genomic locus, including long upstream and downstream regulatory sequences (~80-kb), to fibroblasts extracted from FA patients (which expressed low levels of frataxin) .
Human dendritic cells transduced with herpes simplex virus amplicons encoding human immunodeficiency virus type 1 (HIV-1) gp120 elicit adaptive immune responses from human cells engrafted into NOD/SCID mice and confer partial protection against HIV-1 challenge. J Virol, 2005. 79(4): p. 2124-32. , Effect of promoter strength on protein expression and immunogenicity of an HSV-1 amplicon vector encoding HIV-1 Gag. Vaccine, 2007. 25(9): p. 1634-46. , HSV amplicons: neuro applications. Curr Gene Ther, 2006.
Advances in Viral Genomes Research by John A. Borrelli, Ylenia D. Giannini