By André Bryskier
Annotation Antimicrobial brokers: Antibacterials and Antifungals is an important revision of an unique French reference released by means of Ellipses in 1999. bargains 1000's of antibiotics and antimicrobial compounds: in improvement, experimental, and in useProvides an intensive replace of the unique French variation released in 1999, plus serious new materialPresents entire insurance of chemistry and synthesis, type, constitution & ndash;activity relationships, mechanisms of motion and resistance, breakpoints, in vitro/in vivo actions, epidemiology, pharmacokinetics, metabolism, and hostile eventsFeatures over 1,200 illustrations, over 1,500 tables, and greater than 3,000 referencesPresents new, vast chapters overlaying helicobacter pylori and methicillin & ndash;resistant Staphylococcus aureus (MSRA). �Read more...
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Extra resources for Antimicrobial agents : antibacterials and antifungals
Infant mortality accounted for 27,000 deaths among children aged 1 to 14 years in 1930, compared with 5,000 in 1960. The introduction of streptomycin and then of other antituberculosis agents exerted a spectacular inﬂuence on tuberculosis-related mortality. Scarlet fever, erysipelas, and the other streptococcal skin diseases became curable, and renal and cardiac complications of streptococcal origin declined. The combination of penicillin G and streptomycin provided a treatment for endocarditis of bacterial origin.
The major characteristic of these molecules is their good activity against cephalosporinase-producing strains of enterobacteria. The mechanism of action has been particularly well studied for Citrobacter freundii. These molecules, with their zwitterionic nature, very rapidly penetrate the bacterial wall and reach the periplasmic space that contains the cephalosporinase-like enzymes. They do not have time to be hydrolyzed because they have a twofold characteristic, speed and weak enzymatic affinity, and they bind to penicillin-binding proteins with an afﬁnity similar to that of cefotaxime.
The term antibiotic itself was invented in 1889 by Vuillemin, who also proposed the term antibiont for microorganisms that caused antibiosis. An antibiotic is a derivative produced by the metabolism of microorganisms that possesses antibacterial activity at low concentrations and is not toxic to the host. This concept has been extended to molecules obtained by semisynthesis. The antibacterial agents obtained by total synthesis, such as the quinolones, benzylpyrimidines (co-trimoxazole), nitroheterocycles, and penems, are synthetic antibacterial agents and not antibiotics.
Antimicrobial agents : antibacterials and antifungals by André Bryskier